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may be challenged and removed. (June 2016) (Learn how and when to remove this template message) In statistics, family-wise error rate (FWER) is the probability of making one or more false discoveries, or type I errors, among

all the hypotheses when performing multiple hypotheses tests. Contents 1 History 2 Background 2.1 family wise error rate r Classification of multiple hypothesis tests 3 Definition 4 Controlling procedures 4.1 The Bonferroni procedure 4.2 The Å idÃ¡k procedure 4.3 Tukey's how to calculate family wise error rate procedure 4.4 Holm's step-down procedure (1979) 4.5 Hochberg's step-up procedure 4.6 Dunnett's correction 4.7 ScheffÃ©'s method 4.8 Resampling procedures 5 Alternative approaches 6 References History[edit] Tukey coined the terms experimentwise error rate and "error

rate per-experiment" to indicate error rates that the researcher could use as a control level in a multiple hypothesis experiment.[citation needed] Background[edit] Within the statistical framework, there are several definitions for the term "family": Hochberg & Tamhane defined "family" in 1987 as "any collection of inferences for which it is meaningful to take into account some combined measure of error".[1][pageneeded] According to Cox in 1982, a set of

inferences should be regarded a family:[citation needed] To take into account the selection effect due to data dredging To ensure simultaneous correctness of a set of inferences as to guarantee a correct overall decision To summarize, a family could best be defined by the potential selective inference that is being faced: A family is the smallest set of items of inference in an analysis, interchangeable about their meaning for the goal of research, from which selection of results for action, presentation or highlighting could be made (Yoav Benjamini).[citation needed] Classification of multiple hypothesis tests[edit] Main article: Classification of multiple hypothesis tests The following table defines various errors committed when testing multiple null hypotheses. Suppose we have a number m of multiple null hypotheses, denoted by: H1,H2,...,Hm. Using a statistical test, we reject the null hypothesis if the test is declared significant. We do not reject the null hypothesis if the test is non-significant. Summing the test results over Hi will give us the following table and related random variables: Null hypothesis is true (H0) Alternative hypothesis is true (HA) Total Test is declared significant V {\displaystyle V} S {\displaystyle S} R {\displaystyle R} Test is declared non-significant U {\displaystyle U} T {\displaystyle T}

or FWER. It is easy to show that if you declare tests significant for \(p < \alpha\) then FWER â‰¤ \(min(m_0\alpha,1)\). The most commonly used method family wise error rate correction which controls FWER at level \(\alpha\) is called Bonferroni's method. It rejects

the null hypothesis when \(p < \alpha / m\). (It would be better to use \(m_0\) but we don't experiment wise error rate know what it is - more on that later.) The Bonferroni method is guaranteed to control FWER, but it has a big problem. It greatly reduces your power to detect https://en.wikipedia.org/wiki/Family-wise_error_rate real differences. For example, suppose the effect size is 2 and you are doing a t-test, rejecting for p < 0.05. With 10 observations per group, the power is 99%. Now suppose you have 1000 tests, and use the Bonferroni method. That means that to reject, we need p < 0.00005. The power is now only 29%. If you have 10 https://onlinecourses.science.psu.edu/stat555/node/58 thousand tests (which is small for genomics studies) the power is only 10%. Sometimes the "Bonferroni-adjusted p-values are reported". They are just: \(p_b=min(mp,1)\). Another simple more powerful but less popular method uses the sorted p-values: \[p_{(1)}\leq p_{(2)} \leq \cdots \leq p_{(m)}\] Holmes showed that the FWER is controlled with the following algorithm: Compare \(p_{(i)}\) with \(\alpha / (m-i+1)\). Starting from i = 1, reject until \(p_{(i)}\) is greater. The most significant test must therefore pass the Bonferroni criterion. However, if it is significant, the next most significant is tested at a less stringent level. Heuristically, after rejecting the most significant test, we conclude the \(m_0 \leq m-1\) and use \(m-1\) for the next correction, and so on sequentially. The Holmes method is more powerful than the Bonferroni method, but it is still not very powerful. We can also compute "Holmes-adjusted p-values" \(p_{h(i)} = min((m-i+1)p_{(i)},1)\). â€¹ 4.1 - Mistakes in Statistical Testing up 4.3 -1995 - Two Huge Steps for Biological Inference â€º Printer-friendly version Navigation Start Here! Welcome to STAT 555! Faculty login (PSU Access Account) Lessons Lesson 1: Introduction to C

describe a number of different ways of testing which means are different Before describing the tests, it is necessary to consider two different ways of thinking about error and how they are relevant to doing multiple comparisons Error Rate per Comparison (PC) This is simply the Type I error that we http://www.psych.utoronto.ca/courses/c1/chap12/chap12.html have talked about all along. So far, we have been simply setting its value at .05, a 5% chance of making an error Familywise Error Rate (FW) Often, after an ANOVA, we want to do a number of comparisons, not just one The collection of comparisons we do is described as the "family" The familywise error rate is the probability that at least one of these comparisons will include a type I error Assuming that a ¢ is the per comparison error rate, then: The per comparison error: a = a ¢ wise error but, the familywise error: a = 1 - (1-a ¢ )c Thus, if we do two comparisons, but keep a ¢ at 0.05, the FWerror will really be: a = 1 - (1 - 0.05)2 =1 - (0.95)2 = 1 - 0.9025 = 0.0975 Thus, there is almost a 10% chance of one of the comparisons being significant when we do two comparisons, even when the nulls are true. The basic problem then, is that if we are doing many comparisons, we want to somehow control our familywise error so that we family wise error don’t end up concluding that differences are there, when they really are not The various tests we will talk about differ in terms of how they do this They will also be categorized as being either "A priori" or "post hoc" A priori: A priori tests are comparisons that the experimenter clearly intended to test before collecting any data Post hoc: Post hoc tests are comparisons the experimenter has decided to test after collecting the data, looking at the means, and noting which means "seem" different. The probability of making a type I error is smaller for A priori tests because, when doing post hoc tests, you are essentially doing all possible comparisons before deciding which to test in a formal statistical manner Steve: Significant F issue An example for context See page 351 for a very complete description of the Morphine Tolerance study .. Seigel (1975) Highlights: paw lick latency as a measure of pain resistance tolerance to morphine develops quickly notion of a compensatory mechanism this mechanism very context dependent M-S M-M S-S S-M Mc - M 3 2 14 29 24 5 12 6 20 26 1 13 12 36 40 8 6 4 21 32 1 10 19 25 20 1 7 3 18 33 4 11 9 26 27 9 19 21 17 30 Total 32 80 88 192 232 Mean 4 10 11 24 29 Var 9.99 26.32 45.16 40.58 37.95 Source df SS MS F Treatment 4 3497.60 874.40 27.33 Within 35 1120.00 32.00 Total 39 2455.22 A Priori Comparisons As discussed, these tests a

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error wise

Error Wisemay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error experimentwise error definition rate FWER is the probability of making one or more Comparison Wise Error Rate false discoveries or type I errors among all the hypotheses when performing multiple hypotheses tests How To Calculate Family Wise Error Rate Contents History Background Classification of multiple hypothesis tests Definition Controlling procedures The Bonferroni procedure The id k procedure Decision Wise Error Rate Tukey's procedure Holm's step-down procedure Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative approaches References History

experiment wise error correction

Experiment Wise Error Correctionmay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the probability of making one or more false experiment wise error rate definition discoveries or type I errors among all the hypotheses when performing multiple Comparison Wise Error Rate hypotheses tests Contents History Background Classification of multiple hypothesis tests Definition Controlling procedures how to calculate family wise error rate The Bonferroni procedure The id k procedure Tukey's procedure Holm's step-down procedure Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative Decision Wise Error

experimentwise and comparison wise error rate

Experimentwise And Comparison Wise Error Ratethe experimentwise error rate is where alpha ew Experimentwise Alpha is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons per comparison error rate were each to be done at the level then the probability that at least one of them would result in a Type I error is - - If the comparisons are not independent then the experimentwise error rate is less than Finally regardless of whether the comparisons are independent alpha ew le c alpha pc For this example

experiment wise error

Experiment Wise Errorthe experimentwise error rate is where alpha ew comparison wise error is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons type error were each to be done at the level then the probability that at least one of them would result in a Type I error is - - If the comparisons are not independent then the experimentwise error rate is less than Finally regardless of whether the comparisons are independent alpha ew le c alpha pc For this example Descriptive Statistics Hypothesis Testing

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Experimentwise Error Rate Wikipediamay be challenged and removed June Learn how and when to remove this template message An example of data produced by data dredging apparently showing a close link between the familywise error rate calculator letters in the winning word used in a spelling bee competition and Experiment Wise Error the number of people in the United States killed by venomous spiders The clear similarity in trends is a comparison wise error rate coincidence If many data series are compared similarly convincing but coincidental data may be obtained In statistics the multiple comparisons multiplicity or multiple testing problem

experimentwise error

Experimentwise Errorthe experimentwise error rate is where alpha ew Experimentwise Alpha is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons type error were each to be done at the level then the probability that at least one of them would result in a Type I error is - - If the comparisons are not independent then the experimentwise error rate is less than Finally regardless of whether the comparisons are independent alpha ew le c alpha pc For this example Descriptive Statistics Hypothesis Testing General Properties

experimental wise error correction

Experimental Wise Error Correctionmay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the Family Wise Error Correction probability of making one or more false discoveries or type family wise error rate correction I errors among all the hypotheses when performing multiple hypotheses tests Contents History Background experiment wise error anova Classification of multiple hypothesis tests Definition Controlling procedures The Bonferroni procedure The id k procedure Tukey's procedure Holm's step-down procedure Experiment Wise Error Definition Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative approaches References

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Family Wise Error Anovadescribe a number of different ways of testing which means are different Before describing the tests it is necessary to consider two different ways of thinking about error and how they are relevant how to calculate family wise error rate to doing multiple comparisons Error Rate per Comparison PC This is simply the Type I error Family Wise Error Calculator that we have talked about all along So far we have been simply setting its value at a chance of making Experiment Wise Error Rate an error Familywise Error Rate FW Often after an ANOVA we want

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Family Wise Error Rate Fmrimay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the probability of making one or more false discoveries or type I errors among all the hypotheses when family wise error rate post hoc performing multiple hypotheses tests Contents History Background Classification of multiple hypothesis family wise error rate r tests Definition Controlling procedures The Bonferroni procedure The id k procedure Tukey's procedure Holm's step-down procedure How To Calculate Family Wise Error Rate Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative

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Family Wise Error Rate Rmay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the probability of making one or more false family wise error rate post hoc discoveries or type I errors among all the hypotheses when performing multiple hypotheses Familywise Error Rate tests Contents History Background Classification of multiple hypothesis tests Definition Controlling procedures Familywise Error Rate Anova The Bonferroni procedure The id k procedure Tukey's procedure Holm's step-down procedure Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative approaches Familywise Error Rate Calculator

familywise error

Familywise Errormay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the probability of making one or more false discoveries or type I errors family wise error rate definition among all the hypotheses when performing multiple hypotheses tests Contents History family wise error t tests Background Classification of multiple hypothesis tests Definition Controlling procedures The Bonferroni procedure The id k procedure family wise error bonferroni Tukey's procedure Holm's step-down procedure Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative approaches References History edit Tukey coined the

family wise error rate anova

Family Wise Error Rate Anovamay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the familywise error rate anova probability of making one or more false discoveries or type I Family Wise Error Rate Post Hoc errors among all the hypotheses when performing multiple hypotheses tests Contents History Background Family Wise Error Rate R Classification of multiple hypothesis tests Definition Controlling procedures The Bonferroni procedure The id k procedure Tukey's procedure Holm's step-down procedure Hochberg's How To Calculate Family Wise Error Rate step-up procedure Dunnett's correction Scheff 's

family rate error

Family Rate Errormay be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the probability of making one or more false discoveries or type family wise error rates I errors among all the hypotheses when performing multiple hypotheses tests Contents Decision Wise Error Rate History Background Classification of multiple hypothesis tests Definition Controlling procedures The Bonferroni procedure Individual Error Rate The id k procedure Tukey's procedure Holm's step-down procedure Hochberg's step-up procedure Dunnett's correction Scheff 's method Resampling procedures Alternative approaches References History edit Tukey coined the Familywise Error

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family wise error fmri

Family Wise Error Fmrian excellent introduction to the issue of FWE in neuroimaging in very readable fashion You're encouraged to check it out Many scientific fields have had to confront the problem of assessing statistical significance in family wise error correction the context of multiple tests With a single statistical test the standard Family Wise Error Calculator conventionally dictates a statistic is significant if it is less than likely to occur by chance - a can parametric statistical methods be trusted for fmri based group studies p-threshold of But in fields like DNA microassays or neuroimaging many thousands of tests

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